Reaction Details |
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Target | Thyroid hormone receptor beta |
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Ligand | BDBM86689 |
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Substrate/Competitor | n/a |
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Ki | >10000±n/a nM |
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Citation | Jacobson, PB; von Geldern, TW; Ohman, L; Osterland, M; Wang, J; Zinker, B; Wilcox, D; Nguyen, PT; Mika, A; Fung, S; Fey, T; Goos-Nilsson, A; Grynfarb, M; Barkhem, T; Marsh, K; Beno, DW; Nga-Nguyen, B; Kym, PR; Link, JT; Tu, N; Edgerton, DS; Cherrington, A; Efendic, S; Lane, BC; Opgenorth, TJ Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. J Pharmacol Exp Ther314:191-200 (2005) [PubMed] Article |
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More Info.: | Get all data from this article |
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Thyroid hormone receptor beta |
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Name: | Thyroid hormone receptor beta |
Synonyms: | Erba2 | Nr1a2 | THB_RAT | Thrb | Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1 | thyroid beta |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 52661.52 |
Organism: | RAT |
Description: | thyroid beta 0 RAT::P18113 |
Residue: | 461 |
Sequence: | MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQ
ATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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BDBM86689 |
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n/a |
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Name | BDBM86689 |
Synonyms: | CAS_84371-65-3 | NSC_55245 | RU-486 |
Type | Small organic molecule |
Emp. Form. | C29H35NO2 |
Mol. Mass. | 429.5937 |
SMILES | CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)c1ccc(cc1)N(C)C |c:18,t:11| |
Structure |
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