| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
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| Ligand | BDBM161911 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALK1-6 enzymatic assays |
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| pH | 7.5±n/a |
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| IC50 | 3740±n/a nM |
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| Comments | extracted |
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| Citation |  Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1B |
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| Name: | Bone morphogenetic protein receptor type-1B |
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| Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56939.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00238 |
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| Residue: | 502 |
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| Sequence: | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
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| BDBM161911 |
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| n/a |
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| Name | BDBM161911 |
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| Synonyms: | US10017516, Compound 43 | US9682983, 43 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N7O |
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| Mol. Mass. | 465.5496 |
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| SMILES | CN1CCN(CCOc2ccc(cn2)-c2cnc3c(cnn3c2)-c2ccnc3ccccc23)CC1 |
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| Structure | 
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