Ki Summary

Reaction Details

Report a problem with these data

Target

Histone-lysine N-methyltransferase PRDM9 [195-385]

Ligand

BDBM228652

Substrate/Competitor

n/a

Meas. Tech.

Radioactivity-Based Assay

8.5±n/a

Temperature

296.15±n/a K

4.2e+3±n/a nM

Comments

extracted

Citation

Eram, MS; Bustos, SP; Lima-Fernandes, E; Siarheyeva, A; Senisterra, G; Hajian, T; Chau, I; Duan, S; Wu, H; Dombrovski, L; Schapira, M; Arrowsmith, CH; Vedadi, M Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. J Biol Chem289:12177-88 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Histone-lysine N-methyltransferase PRDM9 [195-385]

Name:

Histone-lysine N-methyltransferase PRDM9 [195-385]

Synonyms:

PFM6 | PR domain-containing protein 9 (PRDM9) | PRDM9 | PRDM9_HUMAN

Type:

Protein

Mol. Mass.:

21772.09

Organism:

Homo sapiens (Human)

Description:

Human PRDM9 truncation (195-385 aa)

Residue:

191

Sequence:

SEPQDDDYLYCEMCQNFFIDSCAAHGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGIP
QAGLGVWNEASDLPLGLHFGPYEGRITEDEEAANNGYSWLITKGRNCYEYVDGKDKSWAN
WMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPGCELLVWYGDEYGQELGIKWGSKWK
KELMAGREPKP

BDBM228652

n/a

Name

BDBM228652

Synonyms:

H3 (21-44) K36me2 | LATKAARKSAPSTGGVKKPHRYRP

Type

Small organic molecule

Emp. Form.

C115H198N39O30

Mol. Mass.

2607.0454

SMILES

CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCC[NH+](C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(O)=O |r|

Structure