| Reaction Details |
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 | Report a problem with these data |
| Target | Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/N-formyl peptide receptor 2 |
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| Ligand | BDBM230860 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Intracellular Calcium Assay |
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| EC50 | 82.3±n/a nM |
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| Citation |  Bur, D; Corminboeuf, O; Cren, S; Grisostomi, C; Leroy, X; Richard-Bildstein, S Hydroxylated aminotriazole derivatives as ALX receptor agonists US Patent US9346793 Publication Date 5/24/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/N-formyl peptide receptor 2 |
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| Name: | Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/N-formyl peptide receptor 2 |
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| Synonyms: | ALX receptor and the G-protein Gα16 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | N-formyl peptide receptor 2 |
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| Synonyms: | ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 38968.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25090 |
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| Residue: | 351 |
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| Sequence: | METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVT
TICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIA
LDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNF
ASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPL
RVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPM
LYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
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| Component 2 |
| Name: | Guanine nucleotide-binding protein subunit alpha-15 |
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| Synonyms: | G protein alpha 16 | G-protein subunit alpha-16 | G-protein subunit alpha-16 (G alpha-16) | GNA15 | GNA15_HUMAN | GNA16 | Guanine nucleotide-binding protein subunit alpha-15 [Y147C] |
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| Type: | Protein |
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| Mol. Mass.: | 43577.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30679 |
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| Residue: | 374 |
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| Sequence: | MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIK
QMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQD
PYKVTTFEKRYAAAMQWLWRDAGIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQ
DVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQ
CLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQG
PKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVR
DSVLARYLDEINLL
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| BDBM230860 |
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| n/a |
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| Name | BDBM230860 |
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| Synonyms: | US9346793, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17FN6O3S |
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| Mol. Mass. | 428.44 |
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| SMILES | CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncsc3-c3cccc(F)c3)n2)n1 |
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| Structure | 
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