| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sucrase-isomaltase, intestinal |
|---|
| Ligand | BDBM233001 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro α-Glucosidase Inhibitory Assay |
|---|
| pH | 6.8±n/a |
|---|
| IC50 | 9.94e+4±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Kumar, JA; Tiwari, AK; Ali, AZ; Madhusudhana, K; Reddy, BS; Ramakrishna, S; China Raju, B New antihyperglycemic, alpha-glucosidase inhibitory, and cytotoxic derivatives of benzimidazoles. J Enzyme Inhib Med Chem25:80-6 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sucrase-isomaltase, intestinal |
|---|
| Name: | Sucrase-isomaltase, intestinal |
|---|
| Synonyms: | SUIS_RAT | Si | Sucrase-isomaltase | alpha-Glucosidase (α-Glucosidase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 210329.04 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P23739 |
|---|
| Residue: | 1841 |
|---|
| Sequence: | MAKKKFSALEISLIVLFIIVTAIAIALVTVLATKVPAVEEIKSPTPTSNSTPTSTPTSTS
TPTSTSTPSPGKCPPEQGEPINERINCIPEQHPTKAICEERGCCWRPWNNTVIPWCFFAD
NHGYNAESITNENAGLKATLNRIPSPTLFGEDIKSVILTTQTQTGNRFRFKITDPNNKRY
EVPHQFVKEETGIPAADTLYDVQVSENPFSIKVIRKSNNKVLCDTSVGPLLYSNQYLQIS
TRLPSEYIYGFGGHIHKRFRHDLYWKTWPIFTRDEIPGDNNHNLYGHQTFFMGIGDTSGK
SYGVFLMNSNAMEVFIQPTPIITYRVTGGILDFYIFLGDTPEQVVQQYQEVHWRPAMPAY
WNLGFQLSRWNYGSLDTVSEVVRRNREAGIPYDAQVTDIDYMEDHKEFTYDRVKFNGLPE
FAQDLHNHGKYIIILDPAISINKRANGAEYQTYVRGNEKNVWVNESDGTTPLIGEVWPGL
TVYPDFTNPQTIEWWANECNLFHQQVEYDGLWIDMNEVSSFIQGSLNLKGVLLIVLNYPP
FTPGILDKVMYSKTLCMDAVQHWGKQYDVHSLYGYSMAIATEQAVERVFPNKRSFILTRS
TFGGSGRHANHWLGDNTASWEQMEWSITGMLEFGIFGMPLVGATSCGFLADTTEELCRRW
MQLGAFYPFSRNHNAEGYMEQDPAYFGQDSSRHYLTIRYTLLPFLYTLFYRAHMFGETVA
RPFLYEFYDDTNSWIEDTQFLWGPALLITPVLRPGVENVSAYIPNATWYDYETGIKRPWR
KERINMYLPGDKIGLHLRGGYIIPTQEPDVTTTASRKNPLGLIVALDDNQAAKGELFWDD
GESKDSIEKKMYILYTFSVSNNELVLNCTHSSYAEGTSLAFKTIKVLGLREDVRSITVGE
NDQQMATHTNFTFDSANKILSITALNFNLAGSFIVRWCRTFSDNEKFTCYPDVGTATEGT
CTQRGCLWQPVSGLSNVPPYYFPPENNPYTLTSIQPLPTGITAELQLNPPNARIKLPSNP
ISTLRVGVKYHPNDMLQFKIYDAQHKRYEVPVPLNIPDTPTSSNERLYDVEIKENPFGIQ
VRRRSSGKLIWDSRLPGFGFNDQFIQISTRLPSNYLYGFGEVEHTAFKRDLNWHTWGMFT
RDQPPGYKLNSYGFHPYYMALENEGNAHGVLLLNSNGMDVTFQPTPALTYRTIGGILDFY
MFLGPTPEIATRQYHEVIGFPVMPPYWALGFQLCRYGYRNTSEIEQLYNDMVAANIPYDV
QYTDINYMERQLDFTIGERFKTLPEFVDRIRKDGMKYIVILAPAISGNETQPYPAFERGI
QKDVFVKWPNTNDICWPKVWPDLPNVTIDETITEDEAVNASRAHVAFPDFFRNSTLEWWA
REIYDFYNEKMKFDGLWIDMNEPSSFGIQMGGKVLNECRRMMTLNYPPVFSPELRVKEGE
GASISEAMCMETEHILIDGSSVLQYDVHNLYGWSQVKPTLDALQNTTGLRGIVISRSTYP
TTGRWGGHWLGDNYTTWDNLEKSLIGMLELNLFGIPYIGADICGVFHDSGYPSLYFVGIQ
VGAFYPYPRESPTINFTRSQDPVSWMKLLLQMSKKVLEIRYTLLPYFYTQMHEAHAHGGT
VIRPLMHEFFDDKETWEIYKQFLWGPAFMVTPVVEPFRTSVTGYVPKARWFDYHTGADIK
LKGILHTFSAPFDTINLHVRGGYILPCQEPARNTHLSRQNYMKLIVAADDNQMAQGTLFG
DDGESIDTYERGQYTSIQFNLNQTTLTSTVLANGYKNKQEMRLGSIHIWGKGTLRISNAN
LVYGGRKHQPPFTQEEAKETLIFDLKNMNVTLDEPIQITWS
|
|
|
|---|
| BDBM233001 |
|---|
| n/a |
|---|
| Name | BDBM233001 |
|---|
| Synonyms: | 6-Nitro-2-(4-pyridyl)-1H-benzo[d]imidazole (3e) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H8N4O2 |
|---|
| Mol. Mass. | 240.2175 |
|---|
| SMILES | [O-][N+](=O)c1ccc2nc([nH]c2c1)-c1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
