Reaction Details |
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Target | Epidermal growth factor receptor [645-1186] |
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Ligand | BDBM49214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | EGFR Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 25740±n/a nM |
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Comments | extracted |
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Citation | Zhu, ZW; Shi, L; Ruan, XM; Yang, Y; Li, HQ; Xu, SP; Zhu, HL Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase. J Enzyme Inhib Med Chem26:37-45 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Epidermal growth factor receptor [645-1186] |
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Name: | Epidermal growth factor receptor [645-1186] |
Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 |
Type: | Protein |
Mol. Mass.: | 60974.10 |
Organism: | Homo sapiens (Human) |
Description: | Human EGFR cytoplasmic domain (645-1186 aa) |
Residue: | 542 |
Sequence: | SIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALL
RILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY
VMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKG
MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE
SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY
MIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDE
EDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDS
FLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPH
YQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPN
GI
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BDBM49214 |
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n/a |
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Name | BDBM49214 |
Synonyms: | 2-Hydroxy-N-p-tolylbenzamide (10) | 2-hydroxy-N-(4-methylphenyl)benzamide | 2-hydroxy-N-(p-tolyl)benzamide | MLS000053968 | N-(4-methylphenyl)-2-oxidanyl-benzamide | SMR000061984 | cid_478805 |
Type | Small organic molecule |
Emp. Form. | C14H13NO2 |
Mol. Mass. | 227.2585 |
SMILES | Cc1ccc(NC(=O)c2ccccc2O)cc1 |
Structure |
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