| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [645-1186] |
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| Ligand | BDBM234321 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EGFR Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 50000±n/a nM |
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| Comments | extracted |
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| Citation |  Zhu, ZW; Shi, L; Ruan, XM; Yang, Y; Li, HQ; Xu, SP; Zhu, HL Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase. J Enzyme Inhib Med Chem26:37-45 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [645-1186] |
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| Name: | Epidermal growth factor receptor [645-1186] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 |
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| Type: | Protein |
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| Mol. Mass.: | 60974.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human EGFR cytoplasmic domain (645-1186 aa) |
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| Residue: | 542 |
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| Sequence: | SIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALL
RILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY
VMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKG
MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE
SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY
MIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDE
EDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDS
FLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPH
YQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPN
GI
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| BDBM234321 |
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| n/a |
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| Name | BDBM234321 |
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| Synonyms: | N-(4-fluorophenyl)-2-hydroxy-5-iodobenzamide (23) |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9FINO2 |
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| Mol. Mass. | 357.1189 |
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| SMILES | Oc1ccc(I)cc1C(=O)Nc1ccc(F)cc1 |
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| Structure | 
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