Reaction Details |
| Report a problem with these data |
Target | UDP-glucuronosyltransferase 1A1 |
---|
Ligand | BDBM13066 |
---|
Substrate/Competitor | β-estradiol |
---|
Meas. Tech. | UDP-glucuronosyltransferase Activity Assay |
---|
IC50 | 1.55e+5± 4.6e+4 nM |
---|
Citation | Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem26:386-93 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
UDP-glucuronosyltransferase 1A1 |
---|
Name: | UDP-glucuronosyltransferase 1A1 |
Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
Type: | Enzyme |
Mol. Mass.: | 59604.34 |
Organism: | Homo sapiens (Human) |
Description: | P22309 |
Residue: | 533 |
Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
|
|
|
BDBM13066 |
---|
β-estradiol |
---|
Name | BDBM13066 |
Synonyms: | 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid | CHEMBL139 | Diclofenac | US11337935, Compound Diclofenac | US11478464, Compound Diclofenac | US11786535, Compound Diclofenac | {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |
Type | Small organic molecule |
Emp. Form. | C14H11Cl2NO2 |
Mol. Mass. | 296.149 |
SMILES | OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl |
Structure |
|