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TargetUDP-glucuronosyltransferase 2B7
LigandBDBM50090677
Substrate/CompetitorDiclofenac
Meas. Tech.UDP-glucuronosyltransferase Activity Assay
IC50>3.00e+5±n/a nM
Citation Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem26:386-93 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-glucuronosyltransferase 2B7
Name:UDP-glucuronosyltransferase 2B7
Synonyms:2.4.1.17 | 3,4-catechol estrogen-specific UDPGT | UD2B7_HUMAN | UDP-glucuronosyltransferase 2B7 | UDP-glucuronosyltransferase 2B9 | UDPGT 2B7 | UDPGT 2B9 | UDPGTh-2 | UGT2B7 | UGTB2B9 | Uridine-5'-diphosphoglucuronosyltransferase 2B7
Type:Enzyme
Mol. Mass.:60705.98
Organism:Homo sapiens (Human)
Description:P16662
Residue:529
Sequence:
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50090677
Diclofenac
NameBDBM50090677
Synonyms:4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide | 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide | CHEMBL1109 | SULFAPHENAZOLE | Sulfabid | Sulphaphenazole | US9180183, Sulfaphenazole
TypeSmall organic molecule
Emp. Form.C15H14N4O2S
Mol. Mass.314.362
SMILESNc1ccc(cc1)S(=O)(=O)Nc1ccnn1-c1ccccc1
Structure
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