| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 2B10 |
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| Ligand | BDBM213826 |
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| Substrate/Competitor | Diclofenac |
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| Meas. Tech. | UDP-glucuronosyltransferase Activity Assay |
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| IC50 | 6.2e+4± 1.8e+4 nM |
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| Citation |  Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem26:386-93 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 2B10 |
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| Name: | UDP-glucuronosyltransferase 2B10 |
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| Synonyms: | UDB10_HUMAN | UGT2B10 | Uridine-5'-diphosphoglucuronosyltransferase 2B10 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60792.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36537 |
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| Residue: | 528 |
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| Sequence: | MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD
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| BDBM213826 |
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| Diclofenac |
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| Name | BDBM213826 |
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| Synonyms: | Dextromethorphan | US11535596, Compound Dextromethorphan (DM) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25NO |
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| Mol. Mass. | 271.3972 |
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| SMILES | COc1ccc2C[C@@H]3[C@H]4CCCC[C@]4(CCN3C)c2c1 |THB:17:16:8:18.6.5| |
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| Structure | 
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