| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 2B10 |
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| Ligand | BDBM21363 |
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| Substrate/Competitor | Diclofenac |
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| Meas. Tech. | UDP-glucuronosyltransferase Activity Assay |
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| IC50 | 1.06e+5± 6e+3 nM |
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| Citation |  Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem26:386-93 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 2B10 |
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| Name: | UDP-glucuronosyltransferase 2B10 |
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| Synonyms: | UDB10_HUMAN | UGT2B10 | Uridine-5'-diphosphoglucuronosyltransferase 2B10 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60792.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36537 |
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| Residue: | 528 |
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| Sequence: | MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD
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| BDBM21363 |
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| Diclofenac |
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| Name | BDBM21363 |
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| Synonyms: | 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine | CHEMBL655 | Dormicum | Midazolam | Ro 21-3981 | US20230416258, Compound Midazolam |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13ClFN3 |
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| Mol. Mass. | 325.767 |
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| SMILES | Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12 |t:6| |
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| Structure | 
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