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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase SMYD3 | ||
| Ligand | BDBM293391 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | SMYD3 Biochemical Assay | ||
| IC50 | 24390±n/a nM | ||
| Citation |  Foley, MA; Kuntz, KW; Mitchell, LH; Munchhof, MJ Substituted isoxazoles for treating cancer US Patent US10106510 Publication Date 10/23/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase SMYD3 | |||
| Name: | Histone-lysine N-methyltransferase SMYD3 | ||
| Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 49101.22 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9H7B4-2 | ||
| Residue: | 428 | ||
| Sequence: |
| ||
| BDBM293391 | |||
| n/a | |||
| Name | BDBM293391 | ||
| Synonyms: | N-((1S,4s)-4-((R)-3- aminobutanamido) cyclohexyl)-5- cyclopropyl-N- methylisoxazole-3- carboxamide | US10106510, Compound 55 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H28N4O3 | ||
| Mol. Mass. | 348.4399 | ||
| SMILES | C[C@@H](N)CC(=O)N[C@H]1CC[C@H](CC1)N(C)C(=O)c1cc(on1)C1CC1 |r,wU:7.6,10.13,1.1,(-9.4,-2.31,;-8.07,-1.54,;-8.07,,;-6.73,-2.31,;-5.4,-1.54,;-5.4,,;-4.07,-2.31,;-2.73,-1.54,;-2.73,,;-1.4,.77,;-.07,,;-.07,-1.54,;-1.4,-2.31,;1.27,.77,;1.27,2.31,;2.6,,;2.6,-1.54,;3.93,.77,;5.18,-.14,;6.43,.77,;5.95,2.23,;4.41,2.23,;7.91,.37,;9,-.72,;9.4,.77,)| | ||
| Structure | 
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