| Reaction Details |
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 | Report a problem with these data |
| Target | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Ligand | BDBM238362 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Yeast FTase Assay |
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| pH | 7.5±n/a |
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| IC50 | 1600±200 nM |
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| Comments | extracted |
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| Citation |  Lethu, S; Bosc, D; Mouray, E; Grellier, P; Dubois, J New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis. J Enzyme Inhib Med Chem28:163-71 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Name: | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | Farnesyltransferase | Farnesyltransferase (FTase) | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 70753 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein farnesyltransferase subunit beta |
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| Synonyms: | CAAX farnesyltransferase subunit beta | DPR1 | FNTB_YEAST | FTase-beta | Farnesyltransferase | RAM1 | Ras proteins prenyltransferase subunit beta | SCG2 | STE16 |
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| Type: | Protein |
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| Mol. Mass.: | 48188.41 |
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| Organism: | Saccharomyces cerevisiae (Baker's yeast) |
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| Description: | P22007 |
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| Residue: | 431 |
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| Sequence: | MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKV
LQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVM
DRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRI
DRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKN
CQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCG
RSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSD
FYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKII
HYFKSNLSSPS
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| Component 2 |
| Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | CAAX farnesyltransferase subunit alpha | FNTA_YEAST | FTase-alpha | Farnesyltransferase | GGTase-I-alpha | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | RAM2 | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37495.69 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_588425 |
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| Residue: | 316 |
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| Sequence: | MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIID
VAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKL
HPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSA
WTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSK
VVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKY
DPIRKNLWHHKINNLN
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| BDBM238362 |
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| n/a |
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| Name | BDBM238362 |
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| Synonyms: | 3-(3-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1k) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15NO3S2 |
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| Mol. Mass. | 333.425 |
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| SMILES | COc1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O |
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| Structure | 
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