| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein farnesyltransferase alpha subunit/subunit beta |
|---|
| Ligand | BDBM238368 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | T. brucei FTase Assay |
|---|
| IC50 | 34000±8000 nM |
|---|
| Citation |  Lethu, S; Bosc, D; Mouray, E; Grellier, P; Dubois, J New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis. J Enzyme Inhib Med Chem28:163-71 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein farnesyltransferase alpha subunit/subunit beta |
|---|
| Name: | Protein farnesyltransferase alpha subunit/subunit beta |
|---|
| Synonyms: | Farnesyltransferase (FTase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | T. brucei FTase |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Protein farnesyltransferase alpha subunit |
|---|
| Synonyms: | Protein farnesyltransferase subunit alpha |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 70116.60 |
|---|
| Organism: | Trypanosoma brucei brucei |
|---|
| Description: | Q9NC77 |
|---|
| Residue: | 612 |
|---|
| Sequence: | MNKSAVRSEESRQSSSLPSTYSSSSLNSEDERLALLSDINALQALFPGVTPKEETPLIKH
PNMTPAVFSKKFDYVMGIYRAVGVTFKGTRVGPSTPQWLLLTSFVIQQNASHYSAWKDRR
DVFLQPSRLVTSTRDAFMAENGQQCCGDKTDSLAKVSQEWLPAQCDVQGPTGECSVWRAI
RWELKAMERFALMNPKNFQVWHHRREMLREALMHANPVVTGSRSAFDGYLLTCHNMQFSD
IDERVFCDAALDDDGKNYHAWLYRSWFVHSFPFLLHPPSWDSLLGGDQGTEDKHSELRAA
PFRSFTVEEDWLHKCLQPIIPECPLSDELTSTAKRILHDCMNNSAWCHRFYVFEHDLIVP
LIRVIPPQQTEEAKLILKRLCECEMFYALQWCAYEPCNESAFVHARCVAVLHQAVAIHLC
LSSHGDAPHVFLRGDETIQVAGSSSLRHINLRDKLRWGAFLETFRLLLCQVNVLSDVITP
RAEEFRSGGEGRDNATISVIHKRRSQFLLDNTHQVYTARYRCLFTILEYMWRCYFTVSDR
ANVAAALPPEVYAGGDAEAAALAQQQSDDCVKFFLEAELQALRLARRLVVEDDIRRKYWK
HEMNIVMNRDYV
|
|
|
|---|
| Component 2 |
| Name: | Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | n/a |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 65426.56 |
|---|
| Organism: | Trypanosoma brucei brucei |
|---|
| Description: | Q9NC76 |
|---|
| Residue: | 585 |
|---|
| Sequence: | MSFVPPPASSTTHAQREVELTLLRFLEKYRPEVCDLWGTHSDIHLHADSNEKEEEMCTID
NEEGIVHSLNRESHEKYLKSRLVKLPEYAQRLYNAQPWMVYWTLQAAEMLGITEKLYEQI
SQDALGEFILSCLQEQPVEDEQKGCWGSEEGGKHGKGSMPQQCGNVYDFLRRCDADHTCA
IGFSGGNYGQIPHLATSYAGVCSLCILGCPEYLQALPRSAIKRWLLSLRCADGSFRMHIG
GEADIRASYCVAVITTLLQLQDVDVRSGDILREQEAQFVASCQTHEGGFACGRFASEAHG
AYTQCGLAALILMKRPELCNYTALRGWLAARQLRFEGGFNGRTNKLVDSCYAHWVGASHV
LLRVGESLAKITTCGETKRSLTSREMLLLDHAQLVDISNLHPESFEAWSQHEEEKQERAS
RVEAYLSATPLAASWSSSGVPNVLDDDAGDFYFNQRRLQLYILACCQNREEGGLMDKPNY
PNDFYHTCYSLSGMSSAQNLQGMQVNRDGRDLSGNSFYAAALSRGYIPGRRDSYGIVLPS
DERSGVSSELHLSKNCLRPTNPIFNINQSKVLFALRTWGAKTFMC
|
|
|
|---|
| BDBM238368 |
|---|
| n/a |
|---|
| Name | BDBM238368 |
|---|
| Synonyms: | 3-(3-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1u) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15NO2S2 |
|---|
| Mol. Mass. | 317.426 |
|---|
| SMILES | CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
