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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein farnesyltransferase alpha subunit/subunit beta | ||
| Ligand | BDBM238375 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | T. brucei FTase Assay | ||
| IC50 | 3300±400 nM | ||
| Citation |  Lethu, S; Bosc, D; Mouray, E; Grellier, P; Dubois, J New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis. J Enzyme Inhib Med Chem28:163-71 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein farnesyltransferase alpha subunit/subunit beta | |||
| Name: | Protein farnesyltransferase alpha subunit/subunit beta | ||
| Synonyms: | Farnesyltransferase (FTase) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | n/a | ||
| Description: | T. brucei FTase | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Protein farnesyltransferase alpha subunit | ||
| Synonyms: | Protein farnesyltransferase subunit alpha | ||
| Type: | Protein | ||
| Mol. Mass.: | 70116.60 | ||
| Organism: | Trypanosoma brucei brucei | ||
| Description: | Q9NC77 | ||
| Residue: | 612 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Protein farnesyltransferase subunit beta | ||
| Synonyms: | n/a | ||
| Type: | Protein | ||
| Mol. Mass.: | 65426.56 | ||
| Organism: | Trypanosoma brucei brucei | ||
| Description: | Q9NC76 | ||
| Residue: | 585 | ||
| Sequence: |
| ||
| BDBM238375 | |||
| n/a | |||
| Name | BDBM238375 | ||
| Synonyms: | 3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1gg) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H15NO3S2 | ||
| Mol. Mass. | 393.479 | ||
| SMILES | CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,8.27,;-.64,7.79,;-1.97,8.56,;-3.3,7.79,;-3.3,6.25,;-1.97,5.48,;-.64,6.25,;.83,5.77,)| | ||
| Structure | 
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