Reaction Details | |||
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Target | Macrophage colony-stimulating factor 1 receptor | ||
Ligand | BDBM238233 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Fluorescence Polarization Competition Immunoassay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.72±n/a nM | ||
Comments | extracted | ||
Citation | Illig, CR; Ballentine, SK; Chen, J; Desjarlais, RL; Meegalla, SK; Wall, M; Wilson, K Inhibitors of c-fms kinase US Patent US9403804 Publication Date 8/2/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Macrophage colony-stimulating factor 1 receptor | |||
Name: | Macrophage colony-stimulating factor 1 receptor | ||
Synonyms: | CSF1R_MOUSE | Csf1r | Csfmr | Fms | Macrophage colony-stimulating factor 1 receptor | Macrophage colony-stimulating factor 1 receptor (c-Fms) | Proto-oncogene c-Fms | ||
Type: | Protein | ||
Mol. Mass.: | 109173.45 | ||
Organism: | Mus musculus (Mouse) | ||
Description: | P09581 | ||
Residue: | 977 | ||
Sequence: |
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BDBM238233 | |||
n/a | |||
Name | BDBM238233 | ||
Synonyms: | US9403804, 44 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H37N5O3 | ||
Mol. Mass. | 503.6358 | ||
SMILES | CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@]1(O)CC[C@@H](CC1)N1CCOCC1 |r,wU:24.27,28.34,wD:24.26,c:5,(-1.39,-2.42,;-2.16,-3.76,;-2.93,-2.42,;-.82,-4.53,;-.82,-6.07,;-2.16,-6.84,;-3.49,-6.07,;-3.49,-4.53,;-2.16,-8.38,;-3.49,-9.15,;-3.49,-10.69,;-2.16,-11.46,;-.82,-10.69,;-.82,-9.15,;.51,-8.38,;1.85,-9.15,;1.85,-10.69,;3.18,-8.38,;4.64,-8.85,;5.59,-7.61,;4.64,-6.36,;3.18,-6.84,;7.13,-7.61,;8.67,-7.61,;-4.82,-11.46,;-5.22,-9.97,;-6.31,-11.86,;-6.71,-13.34,;-5.62,-14.43,;-4.13,-14.03,;-3.73,-12.55,;-6.02,-15.92,;-7.51,-16.32,;-7.9,-17.81,;-6.82,-18.9,;-5.33,-18.5,;-4.93,-17.01,)| | ||
Structure |