| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [1-535] |
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| Ligand | BDBM50382702 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FRET-Based Enzyme-Coupled Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >4000000±n/a nM |
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| Comments | extracted |
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| Citation |  Schonbrunn, E; Li, R; Sebti, SM Inhibitors of rho associated protein kinases (ROCK) and methods of use US Patent US9409868 Publication Date 8/9/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Rho-associated protein kinase 1 [1-535] |
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| Name: | Rho-associated protein kinase 1 [1-535] |
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| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62220.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-535 |
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| Residue: | 535 |
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| Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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| BDBM50382702 |
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| n/a |
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| Name | BDBM50382702 |
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| Synonyms: | CHEMBL2023145 | US9409868, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12FN3O |
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| Mol. Mass. | 293.2951 |
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| SMILES | Fc1ccc(cc1)-c1cncc(c1)C(=O)Nc1ccncc1 |
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| Structure | 
|
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