Reaction Details |
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Target | Rho-associated protein kinase 1 [1-535] |
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Ligand | BDBM50382687 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FRET-Based Enzyme-Coupled Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 2600±600 nM |
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Comments | extracted |
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Citation | Schonbrunn, E; Li, R; Sebti, SM Inhibitors of rho associated protein kinases (ROCK) and methods of use US Patent US9409868 Publication Date 8/9/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Rho-associated protein kinase 1 [1-535] |
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Name: | Rho-associated protein kinase 1 [1-535] |
Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
Type: | Enzyme |
Mol. Mass.: | 62220.48 |
Organism: | Homo sapiens (Human) |
Description: | aa 1-535 |
Residue: | 535 |
Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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BDBM50382687 |
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n/a |
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Name | BDBM50382687 |
Synonyms: | CHEMBL2023152 | US9409868, 16 |
Type | Small organic molecule |
Emp. Form. | C17H18N4O2 |
Mol. Mass. | 310.3504 |
SMILES | COc1ccc(CCNC(=O)Nc2ccc3[nH]ncc3c2)cc1 |
Structure |
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