| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 [1-552] |
|---|
| Ligand | BDBM50382702 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FRET-Based Enzyme-Coupled Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | >4000000±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Schonbrunn, E; Li, R; Sebti, SM Inhibitors of rho associated protein kinases (ROCK) and methods of use US Patent US9409868 Publication Date 8/9/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Rho-associated protein kinase 2 [1-552] |
|---|
| Name: | Rho-associated protein kinase 2 [1-552] |
|---|
| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 63353.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 1-552 |
|---|
| Residue: | 552 |
|---|
| Sequence: | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQI
|
|
|
|---|
| BDBM50382702 |
|---|
| n/a |
|---|
| Name | BDBM50382702 |
|---|
| Synonyms: | CHEMBL2023145 | US9409868, 7 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12FN3O |
|---|
| Mol. Mass. | 293.2951 |
|---|
| SMILES | Fc1ccc(cc1)-c1cncc(c1)C(=O)Nc1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
