| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 [1-552] |
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| Ligand | BDBM50382686 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FRET-Based Enzyme-Coupled Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 670±120 nM |
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| Comments | extracted |
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| Citation |  Schonbrunn, E; Li, R; Sebti, SM Inhibitors of rho associated protein kinases (ROCK) and methods of use US Patent US9409868 Publication Date 8/9/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Rho-associated protein kinase 2 [1-552] |
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| Name: | Rho-associated protein kinase 2 [1-552] |
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| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 63353.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-552 |
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| Residue: | 552 |
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| Sequence: | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQI
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| BDBM50382686 |
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| n/a |
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| Name | BDBM50382686 |
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| Synonyms: | CHEMBL2023154 | US9409868, 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N4O |
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| Mol. Mass. | 280.3244 |
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| SMILES | O=C(NCCc1ccccc1)Nc1ccc2[nH]ncc2c1 |
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| Structure | 
|
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