| Reaction Details |
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 | Report a problem with these data |
| Target | Protein O-GlcNAcase |
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| Ligand | BDBM240645 |
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| Substrate/Competitor | BDBM240663 |
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| Meas. Tech. | Fluorescence-Based Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 0.3±n/a nM |
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| Comments | extracted |
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| Citation |  Li, T; McEachern, E; Vocadlo, D; Zhou, Y; Zhu, Y; Selnick, H Selective glycosidase inhibitors and uses thereof US Patent US9409924 Publication Date 8/9/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein O-GlcNAcase |
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| Name: | Protein O-GlcNAcase |
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| Synonyms: | 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-N-acetylhexosaminidase | Beta-hexosaminidase (O-GlcNAcase) | Bifunctional protein NCOAT | HEXC | KIAA0679 | MEA5 | MGEA5 | N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | OGA | OGA_HUMAN | Protein O-GlcNAcase |
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| Type: | Enzyme |
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| Mol. Mass.: | 102874.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60502 |
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| Residue: | 916 |
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| Sequence: | MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKND
NQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVP
GPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
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| BDBM240645 |
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| BDBM240663 |
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| Name | BDBM240645 |
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| Synonyms: | US9409924, (3aR,5R,6R,7S,7aR)-2-(dimethylamino)-7-fluoro-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazol-6-ol |
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| Type | Small organic molecule |
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| Emp. Form. | C9H15FN2O3S |
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| Mol. Mass. | 250.29 |
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| SMILES | CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2F)S1 |r,t:3| |
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| Structure | 
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