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TargetCoagulation factor IX
LigandBDBM241519
Substrate/CompetitorUS9409908, pyroGlu-Pro-Arg-pNA
Meas. Tech.In Vitro Assay
pH7.4±n/a
Ki 0.84±n/a nM
Commentsextracted
Citation Yang WCorte JRGilligan PJPinto DJEwing WRDilger AKWang YFang TPabbisetty KBSmith, II LM Dihydropyridone p1 as factor XIa inhibitors US Patent  US9409908 Publication Date 8/9/2016
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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  Blast E-value cutoff:
BDBM241519
US9409908, pyroGlu-Pro-Arg-pNA
NameBDBM241519
Synonyms:US9409908, 151
TypeSmall organic molecule
Emp. Form.C30H31ClFN5O4
Mol. Mass.580.05
SMILESCOC(=O)Nc1ccc2-c3nc([nH]c3C)[C@H](CCC[C@@H](C)C(=O)Nc2c1)N1CCC(=CC1=O)c1cccc(Cl)c1F |r,c:32|
Structure
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