| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP [124-214,C202A,C213G] |
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| Ligand | BDBM242804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay |
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| pH | 7.5±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 17±n/a nM |
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| Comments | extracted |
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| Citation |  Donnell, AF; Kester, R; Lou, Y; Anthony, J; Remiszewski, S 2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer US Patent US9422331 Publication Date 8/23/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| E3 ubiquitin-protein ligase XIAP [124-214,C202A,C213G] |
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| Name: | E3 ubiquitin-protein ligase XIAP [124-214,C202A,C213G] |
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| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP (BIR2) | IAP3 | XIAP | XIAP_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 14676.71 |
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| Organism: | Artificial Organism |
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| Description: | P98170[124-214,C202A,C213G] |
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| Residue: | 125 |
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| Sequence: | MRHHHHHHRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPD
YAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDFPNCFFVLGRAWSEHRRHRNL
NIRSE
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| BDBM242804 |
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| n/a |
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| Name | BDBM242804 |
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| Synonyms: | US9422331, 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32BrN5O6S |
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| Mol. Mass. | 670.574 |
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| SMILES | CN[C@@H](C)C(=O)N[C@H]1[C@H](C)N(C(=O)CS(C)(=O)=O)c2ccc(cc2N(Cc2c(OC)ccc3c(Br)cccc23)C1=O)C#N |r| |
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| Structure | 
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