| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM242903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorogenic Inhibition Assay |
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| pH | 8.1±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 47300±n/a nM |
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| Comments | extracted |
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| Citation |  Gleason, JL; White, JH; Kaldre, D; Fischer, J Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer US Patent US9428447 Publication Date 8/30/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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|
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| BDBM242903 |
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| n/a |
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| Name | BDBM242903 |
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| Synonyms: | US9428447, DK-178 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H39NO4S |
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| Mol. Mass. | 461.657 |
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| SMILES | CCC(CC)(c1cc(C)c(CCC(=O)NO)s1)c1ccc(OCC(O)C(C)(C)C)c(C)c1 |w:23.24| |
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| Structure | 
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