| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1973-2419,Y2165H] |
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| Ligand | BDBM243444 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Transient Transfection Assay |
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| EC50 | 10.848±n/a nM |
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| Citation |  Vandyck, K; Last, SJ; Houpis, IN; Raboisson, PJ Benzimidazole-imidazole derivatives US Patent US9433609 Publication Date 9/6/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [1973-2419,Y2165H] |
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| Name: | Genome polyprotein [1973-2419,Y2165H] |
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| Synonyms: | Non-structural protein 5A (NS5A)(Y93H) | POLG_HCVCO | Serine protease NS5A (Y93H) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48680.14 |
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| Organism: | Hepatitis C virus genotype 1b (isolate Con1) (HCV) |
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| Description: | aa 1973-2419 |
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| Residue: | 447 |
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| Sequence: | SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCG
AQITGHVKNGSMRIVGPRTCSNTWHGTFPINAHTTGPCTPSPAPNYSRALWRVAAEEYVE
VTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLN
QYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLK
ATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPA
EILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRT
VVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLE
GEPGDPDLSDGSWSTVSEEASEDVVCC
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| BDBM243444 |
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| n/a |
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| Name | BDBM243444 |
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| Synonyms: | US9427428, 5 | US9433609, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H46N8O6 |
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| Mol. Mass. | 758.8646 |
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| SMILES | COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1 |r| |
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| Structure | 
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