Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM230088 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.330±n/a nM | ||
Comments | extracted | ||
Citation | Batt, DG; Bertrand, MB; Delucca, GV; Galella, MA; Ko, SS; Langevine, CM; Liu, Q; Shi, Q; Srivastava, AS; Tino, JA; Watterson, SH Substituted tetrahydrocarbazole and carbazole carboxamide compounds US Patent US10106559 Publication Date 10/23/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM230088 | |||
n/a | |||
Name | BDBM230088 | ||
Synonyms: | US10106559, Example 48 | US10435415, Example 48 | US9334290, 10 | US9850258, Example 48 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H23ClF2N4O4 | ||
Mol. Mass. | 588.989 | ||
SMILES | Cc1c(cccc1-n1c(=O)[nH]c2c(F)cc(F)cc2c1=O)-c1c(Cl)cc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O |(2.47,,;1.14,-.77,;-.2,,;-1.53,-.77,;-1.53,-2.31,;-.2,-3.08,;1.14,-2.31,;2.47,-3.08,;2.47,-4.62,;1.14,-5.39,;3.8,-5.39,;5.14,-4.62,;6.47,-5.39,;6.47,-6.93,;7.8,-4.62,;7.8,-3.08,;9.14,-2.31,;6.47,-2.31,;5.14,-3.08,;3.8,-2.31,;3.8,-.77,;-.2,1.54,;1.14,2.31,;2.47,1.54,;1.14,3.85,;-.2,4.62,;-.2,6.16,;1.14,6.93,;-1.53,6.93,;-1.53,3.85,;-3,4.33,;-3.9,3.08,;-5.43,2.92,;-6.06,1.51,;-5.15,.27,;-3.62,.43,;-3,1.83,;-1.53,2.31,;-7.6,1.51,;-8.37,.18,;-9.14,1.51,;-8.37,2.85,)| | ||
Structure |