| Reaction Details |
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 | Report a problem with these data |
| Target | Plasma kallikrein |
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| Ligand | BDBM247414 |
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| Substrate/Competitor | BDBM247420 |
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| Meas. Tech. | In Vitro Assay |
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| pH | 7.5±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 24±n/a nM |
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| Citation |  Dilger, AK; Corte, JR; De Lucca, I; Fang, T; Yang, W; Wang, Y; Pabbisetty, KB; Ewing, WR; Zhu, Y; Wexler, RR; Pinto, DJ; Orwat, MJ; Smith, II, LM Pyrimidinones as factor XIa inhibitors US Patent US9453018 Publication Date 9/27/2016 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Plasma kallikrein |
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| Name: | Plasma kallikrein |
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| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
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| Type: | Protein |
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| Mol. Mass.: | 71391.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03952 |
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| Residue: | 638 |
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| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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| BDBM247414 |
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| BDBM247420 |
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| Name | BDBM247414 |
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| Synonyms: | US10336754, Example 368 | US11053247, Example 368 | US9453018, 367 | US9453018, 368 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25ClF3N9O2 |
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| Mol. Mass. | 624.016 |
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| SMILES | C[C@@H]1CCC[C@@H](c2cc(ccn2)-c2c(NC1=O)cnn2C)n1cnc(cc1=O)-c1cc(Cl)ccc1-n1cc(nn1)C(F)(F)F |r| |
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| Structure | 
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