| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasma kallikrein |
|---|
| Ligand | BDBM247416 |
|---|
| Substrate/Competitor | BDBM247420 |
|---|
| Meas. Tech. | In Vitro Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| Ki | 33±n/a nM |
|---|
| Citation |  Dilger, AK; Corte, JR; De Lucca, I; Fang, T; Yang, W; Wang, Y; Pabbisetty, KB; Ewing, WR; Zhu, Y; Wexler, RR; Pinto, DJ; Orwat, MJ; Smith, II, LM Pyrimidinones as factor XIa inhibitors US Patent US9453018 Publication Date 9/27/2016 |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Plasma kallikrein |
|---|
| Name: | Plasma kallikrein |
|---|
| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 71391.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03952 |
|---|
| Residue: | 638 |
|---|
| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
|
|
|
|---|
| BDBM247416 |
|---|
| BDBM247420 |
|---|
| Name | BDBM247416 |
|---|
| Synonyms: | US10336754, Example 369 | US11053247, Example 369 | US9453018, 369 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H23ClF5N9O2 |
|---|
| Mol. Mass. | 659.997 |
|---|
| SMILES | C[C@@H]1CCC[C@@H](c2cc(ccn2)-c2c(NC1=O)cnn2C(F)F)n1cnc(cc1=O)-c1cc(Cl)ccc1-n1cc(nn1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
