Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP [241-356] |
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Ligand | BDBM249163 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Polarization Assay |
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Temperature | 298.15±n/a K |
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IC50 | 0.06±n/a nM |
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Comments | extracted |
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Citation | Borzilleri, RM; Perez, HL; Wei, DD; Kim, KS IAP antagonists US Patent US9453048 Publication Date 9/27/2016 |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase XIAP [241-356] |
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Name: | E3 ubiquitin-protein ligase XIAP [241-356] |
Synonyms: | API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP |
Type: | Protein Binding Domain |
Mol. Mass.: | 13276.62 |
Organism: | Homo sapiens (Human) |
Description: | BIR3 of XIAP: RESIDUES 241-356. |
Residue: | 116 |
Sequence: | SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
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BDBM249163 |
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n/a |
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Name | BDBM249163 |
Synonyms: | US9453048, 4 |
Type | Small organic molecule |
Emp. Form. | C62H79N9O8 |
Mol. Mass. | 1078.3462 |
SMILES | CN[C@@H](C)C(=O)N[C@@H](Cc1ccc(OCc2ccc(cc2)C(=O)NC2C[C@H](N(C2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC2CCCc3ccccc23)cc1)C(=O)N1CC=CCC1C(=O)N[C@@H]1CCCc2ccccc12 |r,c:67| |
Structure |
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