| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP [241-356] |
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| Ligand | BDBM249169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.06±n/a nM |
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| Comments | extracted |
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| Citation |  Borzilleri, RM; Perez, HL; Wei, DD; Kim, KS IAP antagonists US Patent US9453048 Publication Date 9/27/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase XIAP [241-356] |
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| Name: | E3 ubiquitin-protein ligase XIAP [241-356] |
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| Synonyms: | API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP |
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| Type: | Protein Binding Domain |
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| Mol. Mass.: | 13276.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | BIR3 of XIAP: RESIDUES 241-356. |
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| Residue: | 116 |
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| Sequence: | SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
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| BDBM249169 |
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| n/a |
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| Name | BDBM249169 |
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| Synonyms: | US9453048, 11 | US9453048, 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C63H82N8O8 |
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| Mol. Mass. | 1079.374 |
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| SMILES | CN[C@@H](C)C(=O)NC(Cc1ccc(OCc2ccc(cc2)C(=O)N[C@H]2CC(N(C2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)cc1)C(=O)C1CCCC[C@@H]1C(=O)NC1CCCc2ccccc12 |r| |
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| Structure | 
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