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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [75-147] | ||
| Ligand | BDBM249288 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Amplified Luminescent Proximity Homogeneous Assay (ALPHA) | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 25.1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [75-147] | |||
| Name: | Bromodomain-containing protein 4 [75-147] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1 | ||
| Type: | n/a | ||
| Mol. Mass.: | 8856.55 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD1 (75-147 aa) of O60885 | ||
| Residue: | 73 | ||
| Sequence: |
| ||
| BDBM249288 | |||
| n/a | |||
| Name | BDBM249288 | ||
| Synonyms: | US10017501, Compound 1020-78 | US9458145, 1020-78 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H19F2N5O | ||
| Mol. Mass. | 383.3946 | ||
| SMILES | Cc1n[nH]c(C)c1-c1cc(cc2nc([nH]c12)C1CC1(F)F)-c1c(C)noc1C |(1.15,-3.3,;2.49,-2.53,;3.95,-3,;4.86,-1.76,;3.95,-.51,;4.72,.82,;2.49,-.99,;1.15,-.22,;1.15,1.32,;-.18,2.09,;-1.52,1.32,;-1.52,-.22,;-2.66,-1.25,;-2.03,-2.66,;-.5,-2.49,;-.18,-.99,;-2.43,-4.14,;-2.03,-5.63,;-3.52,-5.23,;-4.86,-4.46,;-4.86,-6,;-.18,3.63,;-1.43,4.54,;-2.76,3.77,;-.95,6,;.59,6,;1.06,4.54,;2.4,3.77,)| | ||
| Structure | 
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