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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [75-147] | ||
| Ligand | BDBM249290 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Amplified Luminescent Proximity Homogeneous Assay (ALPHA) | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 50.7±n/a nM | ||
| Comments | extracted | ||
| Citation |  Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [75-147] | |||
| Name: | Bromodomain-containing protein 4 [75-147] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1 | ||
| Type: | n/a | ||
| Mol. Mass.: | 8856.55 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD1 (75-147 aa) of O60885 | ||
| Residue: | 73 | ||
| Sequence: |
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| BDBM249290 | |||
| n/a | |||
| Name | BDBM249290 | ||
| Synonyms: | US10017501, Compound 1020-81 | US9458145, 1020-81 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H22N6O | ||
| Mol. Mass. | 362.4283 | ||
| SMILES | Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NC3CC3)nc12)-c1c(C)noc1C |(1.56,-3.92,;2.9,-3.15,;4.36,-3.63,;5.27,-2.38,;4.36,-1.13,;5.13,.2,;2.9,-1.61,;1.56,-.84,;1.56,.7,;.23,1.47,;-1.1,.7,;-1.1,-.84,;-2.25,-1.87,;-1.62,-3.28,;-2.39,-4.61,;-3.93,-4.61,;-5.27,-3.84,;-5.27,-5.38,;-.09,-3.12,;.23,-1.61,;.23,3.01,;-1.02,3.92,;-2.35,3.15,;-.54,5.38,;1,5.38,;1.48,3.92,;2.81,3.15,)| | ||
| Structure | 
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