| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM294226 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | >40000±n/a nM |
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| Citation |  Gulcan, HO; Unlu, S; Esiringu, I; Sahin, Y; Ercetin, T; Oz, D; Sahin, F 1-(dimethylamino)ethyl-substituted 6H-benzo[C]chromen-6-ones against senile dementia US Patent US9586925 Publication Date 3/7/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
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| Type: | Enzyme |
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| Mol. Mass.: | 67792.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22303 |
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| Residue: | 614 |
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| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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| BDBM294226 |
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| n/a |
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| Name | BDBM294226 |
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| Synonyms: | (±)-1-(1-(dimethylamino)ethyl)-6-oxo-6H-benzo[c]chromen-3-yl ethyl(methyl)carbamate | US9586925, Compound FAR-01-1CA | US9586925, EXAMPLE XXI |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N2O4 |
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| Mol. Mass. | 368.4263 |
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| SMILES | CCN(C)C(=O)Oc1cc(C(C)N(C)C)c2c(c1)oc(=O)c1ccccc21 |
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| Structure | 
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