| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma [262-507] |
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| Ligand | BDBM253264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity Assay (SPA) |
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| Temperature | 298.15±n/a K |
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| IC50 | 18±n/a nM |
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| Comments | extracted |
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| Citation |  Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Pyrrolidinyl sulfone RORγ modulators US Patent US9458171 Publication Date 10/4/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Nuclear receptor ROR-gamma [262-507] |
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| Name: | Nuclear receptor ROR-gamma [262-507] |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 28605.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 262-507 |
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| Residue: | 246 |
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| Sequence: | APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFS
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| BDBM253264 |
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| n/a |
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| Name | BDBM253264 |
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| Synonyms: | US9458171, 224 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H24F9N3O4S |
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| Mol. Mass. | 717.601 |
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| SMILES | Fc1ccc(cc1)S(=O)(=O)[C@]1(CCN(C1)C(=O)Nc1ccncc1)c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F |r| |
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| Structure | 
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