| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM254063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cholesteryl Ester Transfer Assay |
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| IC50 | 7.5±n/a nM |
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| Citation |  Lee, JK; Oh, JT; Lee, JW; Lee, SH; Kim, I; Lee, JY; Bae, SY; Lee, SR; Kim, YT Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors US Patent US9493430 Publication Date 11/15/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM254063 |
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| n/a |
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| Name | BDBM254063 |
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| Synonyms: | US9493430, 729 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H29ClF9NO4 |
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| Mol. Mass. | 734.048 |
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| SMILES | C[C@H]1[C@H](OC(=O)N1CC1=C(CCC(C)(C)C1)c1cc(ccc1Cl)-c1ccc(cc1C(F)(F)F)C(O)=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,t:9| |
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| Structure | 
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