Reaction Details |
| Report a problem with these data |
Target | Complement factor D |
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Ligand | BDBM254450 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Human Complement Factor D Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 78±n/a nM |
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Comments | extracted |
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Citation | Altmann, E; Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Quancard, J; Randl, SA; Rogel, O; Vulpetti, A Pyrrolidine derivatives and their use as complement pathway modulators US Patent US9468661 Publication Date 10/18/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Complement factor D |
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Name: | Complement factor D |
Synonyms: | Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D |
Type: | Protein |
Mol. Mass.: | 27039.19 |
Organism: | Homo sapiens (Human) |
Description: | P00746 |
Residue: | 253 |
Sequence: | MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
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BDBM254450 |
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n/a |
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Name | BDBM254450 |
Synonyms: | US9468661, 28 |
Type | Small organic molecule |
Emp. Form. | C24H31N5O3 |
Mol. Mass. | 437.5346 |
SMILES | C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12)C1CCCCC1 |r| |
Structure |
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