| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] |
|---|
| Ligand | BDBM254573 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 37±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martínez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9469597 Publication Date 10/18/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] |
|---|
| Name: | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] |
|---|
| Synonyms: | GST-Lysine Specific Demethylase-1 (LSD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Glutathione S-transferase P |
|---|
| Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 23353.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P09211 |
|---|
| Residue: | 210 |
|---|
| Sequence: | MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
|
|
|
|---|
| Component 2 |
| Name: | Lysine-specific histone demethylase 1A [158-852] |
|---|
| Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine Specific Demethylase-1 (LSD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 77140.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 158-852 |
|---|
| Residue: | 695 |
|---|
| Sequence: | APPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRT
LQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKK
TGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGL
GGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLD
FNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKE
LHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPS
DVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVA
LAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAV
QFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNL
YKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWA
RGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLS
GLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
|
|
|
|---|
| BDBM254573 |
|---|
| n/a |
|---|
| Name | BDBM254573 |
|---|
| Synonyms: | US10214477, Example 32 | US9469597, 32 | US9670136, 32 N1-(2-(3,4-difluorophenyl)cyclopropyl)cyclohexane-1,4-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H20F2N2 |
|---|
| Mol. Mass. | 266.3295 |
|---|
| SMILES | NC1CCC(CC1)NC1CC1c1ccc(F)c(F)c1 |(6.77,3.46,;5.44,2.69,;5.44,1.15,;4.1,.38,;2.77,1.15,;2.77,2.69,;4.1,3.46,;1.44,.38,;.1,1.15,;-.67,2.49,;-1.44,1.15,;-2.77,.38,;-4.1,1.15,;-5.44,.38,;-5.44,-1.16,;-6.77,-1.93,;-4.1,-1.93,;-4.1,-3.46,;-2.77,-1.16,)| |
|---|
| Structure | 
|
|---|
Search and Browse
