| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
|---|
| Ligand | BDBM163989 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioligand Binding Assay |
|---|
| Temperature | 277.15±n/a K |
|---|
| Ki | 15±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Substituted 7-azabicycles and their use as orexin receptor modulators US Patent US9475819 Publication Date 10/25/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin/Hypocretin receptor type 1 |
|---|
| Name: | Orexin/Hypocretin receptor type 1 |
|---|
| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46817.55 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P56718 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
|
|
|
|---|
| BDBM163989 |
|---|
| n/a |
|---|
| Name | BDBM163989 |
|---|
| Synonyms: | US9062078, 120 | US9475819, 120 | US9637496, 120 | US9695183, 120 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19ClFN5O2 |
|---|
| Mol. Mass. | 427.859 |
|---|
| SMILES | Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(Cl)ccc2-n2nccn2)nc1 |THB:6:7:11.10:13| |
|---|
| Structure | 
|
|---|
Search and Browse
