Reaction Details |
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Target | chymase |
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Ligand | BDBM255968 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Chymase Assay |
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pH | 7.5±n/a |
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IC50 | 1±n/a nM |
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Comments | extracted |
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Citation | Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M; Börngen, K Bicyclically substituted uracils and the use thereof US Patent US9481672 Publication Date 11/1/2016 |
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More Info.: | Get all data from this article, Assay Method |
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chymase |
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Name: | chymase |
Synonyms: | n/a |
Type: | Enzyme |
Mol. Mass.: | 27507.42 |
Organism: | Mesocricetus auratus (Golden hamster) |
Description: | A0A1U7QTH6 |
Residue: | 247 |
Sequence: | MLLPALRLLLFLLGSSAEAGKIIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNF
VMTAAHCAGRSITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDHLVLNDIMLLKLKEKA
NLTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILDPQACKHFED
FHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVLRNAKPPSVFTRISHYRPWI
NKILREN
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BDBM255968 |
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n/a |
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Name | BDBM255968 |
Synonyms: | US9481672, 146 |
Type | Small organic molecule |
Emp. Form. | C26H23F3N4O5 |
Mol. Mass. | 528.4798 |
SMILES | Cc1c(Cn2c(=O)c(cn(-c3ccc4n(C)c(=O)n(CC5CC5)c4c3)c2=O)C(O)=O)cccc1C(F)(F)F |
Structure |
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