| Reaction Details |
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 | Report a problem with these data |
| Target | chymase |
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| Ligand | BDBM256028 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Chymase Assay |
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| pH | 7.5±n/a |
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| IC50 | 3±n/a nM |
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| Comments | extracted |
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| Citation |  Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M; Börngen, K Bicyclically substituted uracils and the use thereof US Patent US9481672 Publication Date 11/1/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| chymase |
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| Name: | chymase |
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| Synonyms: | n/a |
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| Type: | Enzyme |
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| Mol. Mass.: | 27507.42 |
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| Organism: | Mesocricetus auratus (Golden hamster) |
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| Description: | A0A1U7QTH6 |
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| Residue: | 247 |
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| Sequence: | MLLPALRLLLFLLGSSAEAGKIIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNF
VMTAAHCAGRSITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDHLVLNDIMLLKLKEKA
NLTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILDPQACKHFED
FHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVLRNAKPPSVFTRISHYRPWI
NKILREN
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| BDBM256028 |
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| n/a |
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| Name | BDBM256028 |
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| Synonyms: | US9481672, 206 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19ClF3N3O5 |
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| Mol. Mass. | 521.873 |
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| SMILES | CN1C(=O)C(C)(C)c2ccc(cc12)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O |
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| Structure | 
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