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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [172-833] | ||
| Ligand | BDBM256666 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibitory Activity Assay | ||
| pH | 8±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <100±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsumoto, S; Hattori, Y; Toyofuku, M; Morimoto, S; Daini, M; Kojima, T; Kaku, T; Ito, M Cyclopropanamine compound and use thereof US Patent US9487511 Publication Date 11/8/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutathione S-transferase P/Lysine-specific histone demethylase 1A [172-833] | |||
| Name: | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [172-833] | ||
| Synonyms: | GST-Lysine-specific histone demethylase 1A (LSD1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Glutathione S-transferase P | ||
| Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 23353.53 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P09211 | ||
| Residue: | 210 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Lysine-specific histone demethylase 1A [172-833] | ||
| Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A (LSD1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 73571.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | aa 172-833 | ||
| Residue: | 662 | ||
| Sequence: |
| ||
| BDBM256666 | |||
| n/a | |||
| Name | BDBM256666 | ||
| Synonyms: | BDBM256667 | US9487511, 45 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H29F2N3OS | ||
| Mol. Mass. | 397.526 | ||
| SMILES | NC1CCC(CC1)N[C@@H]1C[C@@H]1c1cc(cs1)C(=O)NC1CCC(F)(F)CC1 |r,wD:8.8,10.12,(10.15,-.4,;8.66,-.8,;8.26,-2.29,;6.78,-2.69,;5.69,-1.6,;6.08,-.11,;7.57,.29,;4.2,-1.99,;3.11,-.91,;2.02,-1.99,;1.62,-.51,;.53,.58,;-.93,.11,;-1.84,1.35,;-.93,2.6,;.53,2.12,;-3.38,1.35,;-4.15,2.69,;-4.15,.02,;-5.69,.02,;-6.78,1.11,;-8.26,.71,;-8.66,-.78,;-10.15,-1.18,;-9.75,.31,;-7.57,-1.87,;-6.08,-1.47,)| | ||
| Structure | 
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