Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM118446 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Receptor Radioligand Binding Assay |
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Temperature | 298.15±n/a K |
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Ki | 180±n/a nM |
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Comments | extracted |
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Citation | Letavic, MA; Rudolph, DA; Savall, BM; Shireman, BT; Swanson, D Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators US Patent US9586962 Publication Date 3/7/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM118446 |
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n/a |
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Name | BDBM118446 |
Synonyms: | US11059828, Example 99 | US11667644, Example 99 | US8653263, 99 | US9586962, Example 99 | USRE48841, Example 99 |
Type | Small organic molecule |
Emp. Form. | C21H19F4N7O |
Mol. Mass. | 461.4155 |
SMILES | Cc1cc(nc(n1)C(F)(F)F)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-n1nccn1 |
Structure |
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