| Reaction Details |
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 | Report a problem with these data |
| Target | Hsp90 co-chaperone Cdc37 |
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| Ligand | BDBM406712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding to JNPL3 brain Hsp90 |
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| EC50 | 199±n/a nM |
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| Citation |  Chiosis, G; Greengard, P; Dou, F; Luo, W; He, H; Zatorska, D Treatment of neurodegenerative diseases through inhibition of HSP90 US Patent US10336757 Publication Date 7/2/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Hsp90 co-chaperone Cdc37 |
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| Name: | Hsp90 co-chaperone Cdc37 |
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| Synonyms: | CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone |
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| Type: | Molecular Chaperone |
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| Mol. Mass.: | 44453.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16543 |
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| Residue: | 378 |
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| Sequence: | MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
VAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
KDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVH
LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTK
IKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES
LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPG
DPLLEAVPKTGDEKDVSV
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| BDBM406712 |
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| n/a |
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| Name | BDBM406712 |
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| Synonyms: | US10336757, Compound PU-BSI3 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27FIN7O3 |
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| Mol. Mass. | 583.3978 |
|---|
| SMILES | Nc1nc(F)nc2n(CCCN3CCN(CCO)CC3)c(Cc3cc4OCOc4cc3I)nc12 |
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| Structure | 
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