Ki Summary

Reaction Details

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Target

Tumor necrosis factor

Ligand

BDBM407922

Substrate/Competitor

n/a

Meas. Tech.

IRAK4 Monocyte TNFalpha Cell Based Assay

EC50

6.00±n/a nM

Citation

Bacon, EM; Brizgys, G; Chin, E; Chou, C; Cottell, JJ; Link, JO; Taylor, JG; Tse, WC; Wright, NE; Yang, Z; Zhang, JR; Zipfel, SM Pyrrolo[1,2-b]pyridazine derivatives US Patent US10336762 Publication Date 7/2/2019

More Info.:

Get all data from this article, Assay Method

Tumor necrosis factor

Name:

Tumor necrosis factor

Synonyms:

Type:

Enzyme

Mol. Mass.:

25645.11

Organism:

Homo sapiens (Human)

Description:

P01375

Residue:

233

Sequence:

MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

BDBM407922

n/a

Name

BDBM407922

Synonyms:

US10336762, Compound 867 | methyl-d3 (((1R,3r)-3-((2- (3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(((R)-2- fluoro-3-hydroxy-3- methylbutyl)carbamoyl) pyridin-4-yl)amino)cyclo- butyl)methyl)carbamate

Type

Small organic molecule

Emp. Form.

C26H30FN7O4

Mol. Mass.

523.5593

SMILES

COC(=O)NC[C@H]1C[C@@H](C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N |r,wU:6.5,21.23,wD:8.10,(8.95,3.78,;7.61,3.01,;6.28,3.78,;6.28,5.32,;4.94,3.01,;3.61,3.78,;2.28,3.01,;1.88,1.52,;.39,1.92,;.79,3.41,;-.94,1.15,;-.94,-.39,;.39,-1.16,;.39,-2.7,;-.94,-3.47,;-2.28,-2.7,;-2.28,-1.16,;-3.61,-.39,;-3.61,1.15,;-4.94,-1.16,;-6.28,-.39,;-7.61,-1.16,;-7.61,-2.7,;-8.95,-.39,;-10.28,-1.16,;-8.95,1.15,;-10.28,.38,;1.72,-3.47,;1.89,-5,;3.39,-5.32,;4.16,-3.99,;5.67,-3.67,;6.14,-2.2,;5.11,-1.06,;3.61,-1.38,;3.13,-2.84,;7.63,-1.8,;9.12,-1.4,)|

Structure