| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK4 [1-391] |
|---|
| Ligand | BDBM50044668 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Sampson, PB; Liu, Y; Li, S; Forrest, BT; Pauls, HW; Edwards, LG; Feher, M; Patel, NK; Laufer, R Kinase inhibitors and method of treating cancer US Patent US10358436 Publication Date 7/23/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PLK4 [1-391] |
|---|
| Name: | Serine/threonine-protein kinase PLK4 [1-391] |
|---|
| Synonyms: | PLK4 | PLK4_HUMAN | SAK | STK18 | Serine/threonine-protein kinase PLK4 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43940.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 1-391 |
|---|
| Residue: | 391 |
|---|
| Sequence: | MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV
IQDAEERPHSRYLRRAYSSDRSGTSNSQSQA
|
|
|
|---|
| BDBM50044668 |
|---|
| n/a |
|---|
| Name | BDBM50044668 |
|---|
| Synonyms: | CHEMBL3353357 | US10358436, Example A195 | US9907800, Example A196 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H30N4O2 |
|---|
| Mol. Mass. | 490.5955 |
|---|
| SMILES | Cc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCOCC6)cc5)n[nH]c4c3)c2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
