Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2 [888-1187]

Ligand

BDBM410161

Substrate/Competitor

n/a

Meas. Tech.

Caliper mobility shift assay

IC50

>10000±n/a nM

Citation

Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent US10370375 Publication Date 8/6/2019

More Info.:

Get all data from this article, Assay Method

Non-receptor tyrosine-protein kinase TYK2 [888-1187]

Name:

Non-receptor tyrosine-protein kinase TYK2 [888-1187]

Synonyms:

Non-receptor tyrosine-protein kinase TYK2 (aa 888-1187) | TYK2 | TYK2 (aa 888-1187) | TYK2_HUMAN

Type:

Protein

Mol. Mass.:

34527.73

Organism:

Homo sapiens (Human)

Description:

P29597[888-1187]

Residue:

300

Sequence:

DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQE
IDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQI
CEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW
YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL
LERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

BDBM410161

n/a

Name

BDBM410161

Synonyms:

US10370375, Example 9

Type

Small organic molecule

Emp. Form.

C15H22N4O2S2

Mol. Mass.

354.491

SMILES

CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2sccc12 |r,wD:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;.29,4.87,;-1.04,4.1,;-1.04,2.56,;.29,1.79,;1.63,2.56,;-2.38,1.79,;-3.71,2.56,;-2.38,.25,;-3.71,-.52,;-3.71,-2.06,;-2.38,-2.83,;-1.04,-2.06,;.42,-2.54,;1.33,-1.29,;.42,-.05,;-1.04,-.52,)|

Structure