Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 [811-1124] | ||
Ligand | BDBM410174 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Caliper mobility shift assay | ||
IC50 | 260±n/a nM | ||
Citation | Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent US10370375 Publication Date 8/6/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 [811-1124] | |||
Name: | Tyrosine-protein kinase JAK3 [811-1124] | ||
Synonyms: | JAK3 | JAK3 (aa 811-1124) | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (aa 811-1124) | ||
Type: | Protein | ||
Mol. Mass.: | 35601.85 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333[811-1124] | ||
Residue: | 314 | ||
Sequence: |
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BDBM410174 | |||
n/a | |||
Name | BDBM410174 | ||
Synonyms: | US10370375, Example 22 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H21N5O2S | ||
Mol. Mass. | 347.435 | ||
SMILES | CNS(=O)(=O)C[C@H]1CCC(CC1)n1cnc2cnc3[nH]ccc3c12 |r,wD:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;.29,4.87,;-1.04,4.1,;-1.04,2.56,;.29,1.79,;1.63,2.56,;-2.38,1.79,;-3.62,1.79,;-4.25,.38,;-2.96,-.73,;-2.96,-2.27,;-1.63,-3.04,;-.29,-2.27,;1.17,-2.75,;2.08,-1.5,;1.17,-.25,;-.29,-.73,;-1.63,.04,)| | ||
Structure |