Ki Summary

Reaction Details

Report a problem with these data

Target

Tyrosine-protein kinase JAK3 [811-1124]

Ligand

BDBM410174

Substrate/Competitor

n/a

Meas. Tech.

Caliper mobility shift assay

IC50

260±n/a nM

Citation

Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent US10370375 Publication Date 8/6/2019

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK3 [811-1124]

Name:

Tyrosine-protein kinase JAK3 [811-1124]

Synonyms:

JAK3 | JAK3 (aa 811-1124) | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (aa 811-1124)

Type:

Protein

Mol. Mass.:

35601.85

Organism:

Homo sapiens (Human)

Description:

P52333[811-1124]

Residue:

314

Sequence:

CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQR
EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYS
SQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSP
IFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRL
LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAF
TAHPEGKHHSLSFS

BDBM410174

n/a

Name

BDBM410174

Synonyms:

US10370375, Example 22

Type

Small organic molecule

Emp. Form.

C16H21N5O2S

Mol. Mass.

347.435

SMILES

CNS(=O)(=O)C[C@H]1CCC(CC1)n1cnc2cnc3[nH]ccc3c12 |r,wD:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;.29,4.87,;-1.04,4.1,;-1.04,2.56,;.29,1.79,;1.63,2.56,;-2.38,1.79,;-3.62,1.79,;-4.25,.38,;-2.96,-.73,;-2.96,-2.27,;-1.63,-3.04,;-.29,-2.27,;1.17,-2.75,;2.08,-1.5,;1.17,-.25,;-.29,-.73,;-1.63,.04,)|

Structure