| Reaction Details |
|---|
 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP [241-356] |
|---|
| Ligand | BDBM412163 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-FRET Assays for XIAP BIR3 |
|---|
| IC50 | 13.0±n/a nM |
|---|
| Citation |  Flohr, A; Galley, G; Norcross, R; Zorn, N Dimeric compounds US Patent US10398702 Publication Date 9/3/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| E3 ubiquitin-protein ligase XIAP [241-356] |
|---|
| Name: | E3 ubiquitin-protein ligase XIAP [241-356] |
|---|
| Synonyms: | API3 | BIR3 (aa 241-356) | BIR3 domain | BIRC4 | IAP3 | XIAP | XIAP Bir3 | XIAP_HUMAN | amino acids 241-356 of XIAP |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 14548.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P98170[241-356] |
|---|
| Residue: | 125 |
|---|
| Sequence: | MRHHHHHHRSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYA
LGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEEC
LVRTT
|
|
|
|---|
| BDBM412163 |
|---|
| n/a |
|---|
| Name | BDBM412163 |
|---|
| Synonyms: | N-(2-(((S)-3-((2,6- difluorophenyl)carbamoyl)- 2-((S)-2-((S)-2- (methylamino)propanamido)- 2-(tetrahydro-2H-pyran-4- yl)acetyl)isoindolin-5- yl)amino)-2-oxoethyl)-6-(4- fluorobenzyl)-3-methyl-1-(2- ((2R,5R)-5-methyl-2-(((R)-3- methylmorpholino)methyl) piperazin-1- yl)acetyl)indoline-3- carboxamide trihydrochloride | US10398702, Example 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C58H71F3N10O8 |
|---|
| Mol. Mass. | 1093.2417 |
|---|
| SMILES | CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1Cc2ccc(NC(=O)CNC(=O)C3(C)CN(C(=O)CN4C[C@@H](C)NC[C@@H]4CN4CCOC[C@H]4C)c4cc(Cc5ccc(F)cc5)ccc34)cc2[C@H]1C(=O)Nc1c(F)cccc1F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
