| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Ligand | BDBM50021656 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 4.00±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent US10112907 Publication Date 10/30/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39171.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60674[808-1132] |
|---|
| Residue: | 335 |
|---|
| Sequence: | FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
|
|
|
|---|
| BDBM50021656 |
|---|
| n/a |
|---|
| Name | BDBM50021656 |
|---|
| Synonyms: | BARICITINIB | INCB-028050 | LY-3009104 | US10112907, Example 00034 | US10766894, Compound TABLE 1.19 | US10875847, Compound Baricitinib | US11203595, TABLE 1.19 | US11414413, Example Baricitinib | US20230416237, Example baricitinib |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H17N7O2S |
|---|
| Mol. Mass. | 371.417 |
|---|
| SMILES | CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
